Papillary renal neoplasm with reverse polarity and renal clear cell carcinoma: a case report of image–pathology–molecular multidimensional diagnosis and nephron sparing surgery practice

TL;DR

This case report describes a rare instance of two kidney tumors, PRNRP and RCCC, diagnosed and treated with surgery and multidimensional analysis.

Contribution

The novelty lies in the concurrent diagnosis of PRNRP and RCCC in the same kidney, along with a detailed multidimensional diagnostic approach.

Findings

A patient was diagnosed with both PRNRP and RCCC in the same kidney.

Successful partial nephrectomy was performed for both lesions with good outcomes.

The case highlights the importance of multidimensional diagnosis in rare renal tumors.

Abstract

Papillary renal neoplasm with reverse polarity (PRNRP) is a new pathological type of renal tumor, and its incidence is low. It is considered to be an indolent renal tumor at present. It is rare for PRNRP to co-occur with other tumors in the same kidney. Like other renal tumors, patients with PRNRP do not have any specific clinical manifestations. During surgery, we resected a solid and a cystic lesion in the left kidney simultaneously, and performed two partial nephrectomy on the ipsilateral kidney at one time, both with good surgical results. The postoperative pathological results were as follows: (1) solid lesions are PRNRP, and (2) cystic lesions are RCCC. Here, we present a case of PRNRP concurrent with RCCC and review the literature.

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