# Rare variants in NRSN2 cause non-syndromic orofacial cleft through dysregulation of TGF-β signaling

**Authors:** Xiaowen Zheng, Xuqin Liang, Xiantao Wu, Qing He, Chunyan Yin, Yuhua Jiao, Yanhao Wang, Yuxia Hou, Yi Ding, Huaxiang Zhao

PMC · DOI: 10.1016/j.gendis.2025.101865 · 2025-09-23

## Full-text entities

- **Genes:** NRSN2 (neurensin 2) [NCBI Gene 80023] {aka C20orf98, dJ1103G7.6}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}
- **Diseases:** non-syndromic orofacial cleft (MESH:C566121)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12854861/full.md

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Source: https://tomesphere.com/paper/PMC12854861