# Enantioselective Michael Spirocyclization of Palladium Enolates

## TL;DR

A new chemical reaction is developed to create complex 3D carbon structures with high precision.

## Contribution

A novel enantioselective Michael spirocyclization of palladium enolates is introduced.

## Key findings

- The reaction forms adjacent all-carbon quaternary and tertiary stereocenters efficiently.
- Quantum mechanics calculations reveal the mechanism and stereoselectivity origins.

## Abstract

We report an enantioselective and diastereoselective
Michael spirocyclization
reaction of tetrasubstituted palladium enolates. This allows for the
formation of adjacent all-carbon quaternary and tertiary stereocenters
in good yield, dr, and ee. Various subsequent cyclization reactions
enable access to a diverse range of tricyclic scaffolds. The mechanism
of this transformation and the origins of stereoselectivity are investigated
via quantum mechanics calculations.