Preparation and Characterization of Coated ZnFe2O4 Magnetic Nanoparticles for Potential Use as Magnetic Particle Imaging Tracers
Gulsum Caliskan, Sevil Ozer, Muhammad Irfan, Nurcan Dogan
TL;DR
Researchers created and tested magnetic nanoparticles coated with different acids for use in medical imaging, finding them highly effective as tracers.
Contribution
The study introduces novel ZnFe2O4 magnetic nanoparticles coated with citric, ascorbic, and tartaric acids for potential use in magnetic particle imaging.
Findings
Coated ZnFe2O4 nanoparticles showed superparamagnetic behavior and excellent colloidal stability.
Magnetic particle spectroscopy results indicated superior performance compared to commercial tracers in terms of relaxation time and spatial resolution.
Abstract
Magnetic nanoparticles (MNPs) exhibit unique behaviors that make them appealing for a variety of clinical applications, including their use as tracer agents in magnetic particle imaging (MPI) and magnetic resonance imaging (MRI) systems, as heat generators in hyperthermia treatment, and in targeted drug delivery. We prepared maghemite cores (ZnFe2O4) by coprecipitation of Zn(II) and Fe(III) salts with ammonium hydroxide, followed by a mixture under N2 gas. The cores were coated with coating agents: citric acid monohydrate (CA), l-ascorbic acid (AA), and l-(+)-tartaric acid (TA). State-of-the-art techniques characterized their structural and magnetic properties. XRD results showed that all the particles were consistent with the crystal structure of ZnFe2O4, and the average crystallite size ranged from 14 to 19 nm. The hydrodynamic diameters were found between 112 and 218 nm. Zeta…
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Taxonomy
TopicsCharacterization and Applications of Magnetic Nanoparticles · Nanoparticle-Based Drug Delivery · Magnetic Properties and Synthesis of Ferrites