# Association between uric acid and non-alcoholic fatty liver disease in patients with hypertension

## TL;DR

High uric acid levels are linked to non-alcoholic fatty liver disease in people with hypertension, especially in certain groups like males and obese individuals.

## Contribution

This study identifies uric acid as a significant and independent risk factor for NAFLD in hypertensive patients.

## Key findings

- Uric acid levels were independently associated with NAFLD in hypertensive patients.
- Specific subgroups, such as males and obese individuals, showed a stronger link between uric acid and NAFLD.
- Adding uric acid to a baseline model slightly improved the prediction of NAFLD occurrence.

## Abstract

Serum uric acid (UA) is linked to non-alcoholic fatty liver disease (NAFLD), but its role in hypertensive populations remains unclear. This cross-sectional study investigated their association in 1,058 patients with hypertension. Multivariate logistic regression analysis confirmed that UA was independently correlated with NAFLD, whether as a continuous variable or a categorical variable. According to the fully adjusted model, the risk of NAFLD increased by 0.2%, 347.2% and 91.7% for each unit increase in UA, Log10UA and LnUA, respectively (P < 0.05). Multivariate stratified analysis revealed that UA increased the risk of NAFLD in specific subgroups, including males, individuals aged 70–79 years, non-smokers, those without diabetes, and obese individuals (P < 0.05). Receiver operating characteristic (ROC) analysis indicated that UA could not only predict the occurrence of NAFLD but also improve the predictive value of the baseline model for NAFLD (UA, AUC: 0.588; baseline model, AUC: 0.770; baseline model + UA, AUC: 0.772). In conclusion, UA is significantly associated with NAFLD in patients with hypertension and may serve as a predictive risk indicator.