# The many facets of immunometabolism

**Authors:** Joanna Clarke, Claudio Mauro

PMC · DOI: 10.1371/journal.pbio.3003641 · 2026-01-27

## TL;DR

This paper explores how metabolism influences immune function across different biological levels, from molecules to whole systems.

## Contribution

It introduces a collection of articles highlighting diverse aspects of immunometabolism beyond immune cell metabolism.

## Key findings

- Immunometabolism involves molecular, cellular, and systemic metabolic mechanisms.
- The collection explores immunometabolism's role in health and disease.
- The field extends beyond metabolic shifts in immune cells.

## Abstract

Immunometabolism describes more than just metabolic shifts in immune cells. A new collection of articles shines a light on the many facets of immunometabolism, exploring the effects of molecular, cellular, and systemic metabolic mechanisms in health and disease.

Immunometabolism describes more than just metabolic shifts in immune cells. A new collection of articles shines a light on the many facets of immunometabolism, exploring the effects of molecular, cellular, and systemic metabolic mechanisms in health and disease.

## Full-text entities

- **Genes:** CD274 (CD274 molecule) [NCBI Gene 29126] {aka ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1}, PDCD1 (programmed cell death 1) [NCBI Gene 5133] {aka ADMIO4, AIMTBS, CD279, PD-1, PD1, SLEB2}
- **Diseases:** infectious disease (MESH:D003141), cancer (MESH:D009369), type 2 diabetes (MESH:D003924), infections (MESH:D007239), obesity (MESH:D009765), autoimmune diseases (MESH:D001327), bacterial infections (MESH:D001424), metabolic diseases (MESH:D008659), inflammation (MESH:D007249), lung infections (MESH:D012141), diabetes (MESH:D003920), cardiovascular diseases (MESH:D002318)
- **Chemicals:** itaconate (MESH:C005229), succinate (MESH:D019802)
- **Species:** Homo sapiens (human, species) [taxon 9606], gut metagenome (species) [taxon 749906], Mus musculus (house mouse, species) [taxon 10090]

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Source: https://tomesphere.com/paper/PMC12854436