# The association between chronic disease resource utilization and illness uncertainty in COPD patients: a latent profile analysis

**Authors:** Yangjuan Bao, Lili Yang, Jing-yi Zhao, Zhiqian Wang, Leimian Fu, Min Fang, Jin’e Lin

PMC · DOI: 10.7717/peerj.20674 · 2026-01-26

## TL;DR

This study identifies two distinct patterns of resource use among COPD patients and finds that effective resource use is linked to lower illness uncertainty.

## Contribution

The novel contribution is identifying subgroups of COPD patients based on resource utilization patterns and linking them to illness uncertainty.

## Key findings

- Two distinct resource utilization patterns were identified: Suboptimal and Effective Utilization Groups.
- Effective resource utilization is associated with significantly lower illness uncertainty (R2 = 0.587, p < 0.001).
- Targeted interventions based on these patterns could reduce illness uncertainty and improve COPD management.

## Abstract

This study aimed to identify distinct patterns of chronic disease resource utilization among patients with chronic obstructive pulmonary disease (COPD) and to examine their association with illness uncertainty.

A cross-sectional study.

This study enrolled COPD patients hospitalized in the Department of Respiratory Medicine at a tertiary hospital in Zhejiang Province, China, between April and December 2023. All participants completed a general information form, the Chronic Illness Resource Survey (CIRS), and the Mishel Uncertainty in Illness Scale (MUIS). Latent profile analysis (LPA) was conducted to identify subgroups of resource utilization patterns. Subsequently, hierarchical linear regression was employed to assess the associations between these patterns and illness uncertainty. Ethical approval was obtained from the Institutional Review Board of the Fourth Affiliated Hospital of Zhejiang University (Approval No. K2022057).

A total of 308 participants were included. Two latent classes of resource utilization were identified: the Suboptimal Utilization Group (n = 209) and the Effective Utilization Group (n = 99). Patients in the effective utilization group reported significantly lower levels of illness uncertainty (R2 = 0.587, p < 0.001).

Distinct patterns of chronic disease resource utilization exist among COPD patients and are significantly associated with illness uncertainty. Healthcare providers should recognize these subgroups and implement targeted interventions to enhance access to disease-related support resources, thereby mitigating illness uncertainty.

Understanding COPD patients’ varying patterns of resource utilization enables healthcare professionals and related industries to deliver personalized, resource-based interventions tailored to individual needs, ultimately reducing illness-related uncertainty and improving disease management outcomes.

## Linked entities

- **Diseases:** chronic obstructive pulmonary disease (MONDO:0005002), COPD (MONDO:0005002)

## Full-text entities

- **Diseases:** COPD (MESH:D029424), disease (MESH:D004194), Chronic Illness (MESH:D002908)
- **Chemicals:** K2022057 (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12854130/full.md

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Source: https://tomesphere.com/paper/PMC12854130