# Primary breast lymphoma: Case report and literature review

## TL;DR

This paper reports a rare case of primary breast lymphoma in a young woman and reviews similar cases, highlighting chemotherapy as a potential treatment.

## Contribution

The novelty lies in presenting a case of primary breast lymphoma in a young adult and summarizing findings from ten similar cases.

## Key findings

- Primary breast lymphoma is rare but can occur in young women.
- Chemotherapy was used in all cases with mixed outcomes of remission and death.
- Large B-cell non-Hodgkin lymphoma was the most common diagnosis in reviewed cases.

## Abstract

Primary breast lymphoma (PBL) accounts for a small fraction of breast malignancies and is uncommon in young adults, yet it can lead to significant complications. This report describes a case of PBL in a young female patient. An 18-year-old female presented with a mass in the right breast with fever and sweating. Examination revealed a poorly defined right breast mass. Imaging showed a diffuse infiltrative process, and core biopsy with staining identified the lymphoid origin of the infiltrative disease. Chemotherapy was opted for, and follow-up for months has revealed no complications. Ten cases were reviewed. The mean age was (19.7). The most common symptom was a palpable breast mass(s) (60%). Imaging showed variable signal intensities of the breast masses. Immunohistochemistry and flow cytometry of tissue biopsies were the main methods of diagnosis. Large B-cell non-Hodgkin lymphoma was the most common diagnosis (60%). Chemotherapy was utilized in all of the cases with variations regarding regimens. Death and remission were seen in near equal proportions (40% vs 50%). Young women are not exempt from primary breast lymphoma, and chemotherapy might offer fruitful outcomes.