# Assessing craving in cocaine and cocaine base paste users: validation of the Cocaine Craving Questionnaire-Brief in a Chilean sample

**Authors:** Felipe Bustamante, Soledad Labbé, Tomás Arriaza, Ivelisse Huerta, Miguel Cordero Vega, María Elena Alvarado, Alvaro Vergés

PMC · DOI: 10.1186/s13722-026-00647-5 · 2026-01-22

## TL;DR

This study validates a questionnaire to measure cocaine and cocaine base paste craving in Chile, showing it is reliable and works for both substances.

## Contribution

First validation of the Cocaine Craving Questionnaire-Brief for both cocaine and CBP users in a Chilean sample.

## Key findings

- The CCQ-Brief has a unifactorial structure with high internal consistency in a Chilean sample.
- Craving scores correlate with impulsivity, impaired control, and use frequency for both cocaine and CBP.
- The CCQ-Brief performs equivalently for cocaine and CBP users, supporting its applicability in both contexts.

## Abstract

One of the principal components of substance use treatment is the assessment of craving, as it is highly associated with relapse after treatment. The Cocaine Craving Questionnaire-Brief (CCQ-Brief) has emerged as a commonly used tool in the field, relevant in a context like South America, where cocaine and cocaine base paste (CBP) consumption are critical public health issues.

This study aimed to validate the CCQ-Brief in a Chilean sample, exploring for the first time its applicability in both cocaine and CBP use.

Adults in substance use treatment (N = 439, 71,3% male) completed the CCQ-Brief, assessing craving for cocaine and CBP over the past 30 days. Confirmatory factor analysis (CFA) was conducted to test the CCQ-Brief one-factor structure. Convergent validity was analyzed through correlations with related constructs, including impaired control, impulsivity facets, frequency of cocaine/CBP use and related symptomatology.

CFA supported CCQ-Brief one-factor structure, with high internal consistency (α = 0.92 and ω = 0.94 for the 10-item version). Factorial invariance analysis showed that the CCQ-Brief performs equivalently across cocaine and CBP users. Craving scores were moderately to strongly correlated with impaired control dimensions, impulsivity facets, cocaine/CBP use and related symptomatology.

These results show evidence of the CCQ-Brief as a reliable and valid instrument for general craving of cocaine and CBP in a Chilean context, being the first version of the CCQ-Brief that confirms its unifactorial dimension with all its 10 items in the country.

The online version contains supplementary material available at 10.1186/s13722-026-00647-5.

## Linked entities

- **Chemicals:** cocaine (PubChem CID 2826)

## Full-text entities

- **Genes:** CREBBP (CREB binding lysine acetyltransferase) [NCBI Gene 1387] {aka CBP, KAT3A, MKHK1, RSTS, RSTS1}
- **Diseases:** infections (MESH:D007239), alcohol use disorder (MESH:D000437), psychiatric disorders (MESH:D001523), Impulsive Behavior (MESH:D010554), Drug and Alcohol Use (MESH:D019966), Cocaine Craving (MESH:D019970), control (MESH:C536209), psychotic symptoms (MESH:D011618), impulsivity (MESH:D007174), Craving (MESH:C564883), cardiovascular disease (MESH:D002318)
- **Chemicals:** Cocaine (MESH:D003042), CCQ (-), alcohol (MESH:D000438), amphetamines (MESH:D000662)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12853577/full.md

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Source: https://tomesphere.com/paper/PMC12853577