Effect of Cordyceps militaris Extract on Visceral Adipose Tissue Changes After Ovariectomy in Rodents
Kazuya Kusama, Chisaki Fujii, Kanoko Yoshida, Mikihiro Yoshie, Yoshiyuki Adachi, Hiroaki Miyaoka, Kazuhiro Tamura
TL;DR
Cordyceps militaris extract may help reduce obesity and related risks in postmenopausal women by targeting fat and hormone changes in mice.
Contribution
This study demonstrates that Cordyceps militaris extract can mitigate estrogen deficiency-induced obesity in ovariectomized mice.
Findings
CM reduced body weight gain in ovariectomized mice without affecting food intake.
CM suppressed adipogenic markers and oxidative stress in visceral fat.
CM increased uterine weight and antioxidant levels in treated rats.
Abstract
The increasing global prevalence of obesity, exacerbated by factors such as high‐fat diets and reduced physical activity, poses a substantial risk for lifestyle‐related diseases, particularly in postmenopausal women. Premenopausal women initially have a lower incidence of cardiovascular disease than men, but this risk increases after menopause, highlighting menopause as a critical risk factor. Our previous study showed that the extract of Cordyceps militaris (CM) modulates androgen metabolism partially by inhibiting the gene expression of catabolizing enzyme 5α‐reductase. In this study, we investigated the effect of CM on estrogen deficiency‐induced obesity in ovariectomized (OVX) mice fed a 0.1% CM diet (estimated human equivalent dose: 7.5 g/day) for 52 days. OVX mice had increased body weight, which subsequently decreased with CM, without altering daily food intake. Regarding…
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Taxonomy
TopicsFungal Biology and Applications · Polysaccharides and Plant Cell Walls · Seaweed-derived Bioactive Compounds