HT SpaceM enables high-throughput mapping of metabolic diversity at the single-cell level

TL;DR

HT SpaceM is a new high-throughput method for studying metabolism in individual cells, improving sensitivity and scalability.

Contribution

HT SpaceM introduces a scalable and sensitive MALDI workflow for single-cell metabolomics.

Findings

HT SpaceM enables sensitive and reproducible single-cell metabolomic profiling.

The method addresses the lack of scalability in existing single-cell metabolomics techniques.

Abstract

Expanding metabolomic profiling to the single-cell level can reveal metabolic heterogeneity and clinically relevant subpopulations, yet existing methods lack sensitivity and scale. To address this gap, in a recent issue of Cell, Delafiori and colleagues introduce HT SpaceM, a high-throughput MALDI workflow enabling sensitive, reproducible, and scalable single-cell metabolomics.

Expanding metabolomic profiling to the single-cell level can reveal metabolic heterogeneity and clinically relevant subpopulations, yet existing methods lack sensitivity and scale. To address this gap, in a recent issue of Cell, Delafiori and colleagues introduce HT SpaceM, a high-throughput MALDI workflow enabling sensitive, reproducible, and scalable single-cell metabolomics.

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