# Association between temporomandibular disorders and somatization: a narrative review

**Authors:** Qing Xue, Hongyu Ming, Yi Huang, Xin Xiong

PMC · DOI: 10.22514/jofph.2026.004 · 2026-01-12

## TL;DR

This paper reviews the link between temporomandibular disorders and somatization, highlighting their shared symptoms and the need for a biopsychosocial treatment approach.

## Contribution

The paper provides a comprehensive narrative review of the clinical and mechanistic relationship between TMD and somatization.

## Key findings

- TMD patients often show high somatic symptoms, leading to increased pain and psychological distress.
- Central sensitization and neurobiological changes are potential mechanisms linking TMD and somatization.
- Recognizing somatization in TMD is crucial for effective treatment and better outcomes.

## Abstract

Temporomandibular disorders (TMD) are common orofacial pain conditions with 
multifactorial etiologies. Somatization refers to the manifestation of 
psychological distress as physical symptoms in the absence of clear medical 
causes. A growing body of clinical research has recently shown a strong 
association between TMD and somatization. A substantial proportion of TMD 
patients exhibit moderate to high levels of somatic symptoms, leading to greater 
pain intensity, longer disease duration, and heightened psychological distress. 
The TMD-somatization relationship has been underpinned by complex 
pathophysiological interactions and the underlying mechanisms involved, including 
central sensitization (CS), potential biomarkers, nociplastic pain, 
neurobiological changes, and so on. Clinically, recognizing somatization in TMD 
patients is essential, as it can adversely affect treatment outcomes and 
necessitate a biopsychosocial management approach. In this narrative review, we 
summarize the clinical evidence of the TMD-somatization association, discuss the 
underlying mechanisms, explore management implications, and identify directions 
for future research.

## Full-text entities

- **Genes:** IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, SCN10A (sodium voltage-gated channel alpha subunit 10) [NCBI Gene 6336] {aka FEPS2, Nav1.8, PN3, SNS}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}
- **Diseases:** tissue  injury (MESH:D017695), DC (MESH:D054221), chronic headaches (MESH:D020773), Migraine (MESH:D008881), Mental Disorders (MESH:D001523), health (OMIM:603663), pain syndromes (MESH:C538101), jaw-related pain (MESH:D000072716), neuroinflammatory (MESH:D000090862), muscle aches (MESH:D063806), neuropathy (MESH:D009422), myofascial pain (MESH:D009209), RDC (MESH:C535684), fatigue (MESH:D005221), Chronic pain (MESH:D059350), neural dysfunction (MESH:D015441), muscle tension (MESH:D018781), hyperactivity (MESH:D006948), fibromyalgia (MESH:D005356), Depression (MESH:D003866), Somatic Symptom Disorder (MESH:D000071896), organic disease (MESH:D000092124), headaches (MESH:D006261), chronic fatigue syndrome (MESH:D015673), gastrointestinal discomfort (MESH:D005767), jaw or orofacial pain (MESH:D005157), sleep  disturbances (MESH:D012893), functional impairment (MESH:D003072), allodynia (MESH:D006930), TMD (MESH:D013705), CS (MESH:D003807), nerve damage (MESH:D000080902), temporomandibular joint (MESH:D013706), Psychological distress (MESH:D012128), Pain (MESH:D010146), hypersensitivity (MESH:D004342), inflammation (MESH:D007249), irritable bowel syndrome (MESH:D043183), jaw disability (MESH:D007571), Anxiety (MESH:D001007)
- **Chemicals:** adrenaline (MESH:D004837), lipid (MESH:D008055), cortisol (MESH:D006854), venlafaxine (MESH:D000069470), catecholamine (MESH:D002395), inhibitors (-), duloxetine (MESH:D000068736), nortriptyline (MESH:D009661), LOOH (MESH:D008054), serotonin (MESH:D012701), trazodone (MESH:D014196), MDA (MESH:D008315), amitriptyline (MESH:D000639)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12853163/full.md

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Source: https://tomesphere.com/paper/PMC12853163