Enhanced controlled drug delivery of berberine-loaded gelatin nanoparticles: characterization and in vitro assessment
Hoda A. Sharaf, Mohamed A. Abu Saied, Doaa A. Ghareeb, Sherif H. Kandil, Ahmed Abd El-Fattah
TL;DR
Gelatin nanoparticles improve berberine's solubility and bioavailability, enabling controlled release and better antimicrobial and antioxidant effects.
Contribution
A new method for encapsulating berberine in gelatin nanoparticles with controlled release and improved therapeutic properties.
Findings
BBR-loaded gelatin nanoparticles achieved a mean particle size of 215.4 nm and 72.5% encapsulation efficiency.
In vitro studies showed a sustained release profile over three weeks and improved antimicrobial and antioxidant activity.
MTT assays confirmed high cell viability, indicating the formulation's biocompatibility and safety.
Abstract
Berberine (BBR), a natural isoquinoline alkaloid, has long been recognized for its potent antimicrobial properties. However, BBR's therapeutic potential remains limited due to its poor bioavailability, low solubility, and short biological half-life. Nanoencapsulation of BBR within a suitable carrier system represents a promising strategy to overcome these limitations and enhance its pharmacological performance. In this study, BBR-loaded gelatin nanoparticles (BBR-GNPs) were successfully synthesized using a double desolvation technique to achieve controlled release and improved antimicrobial efficacy. FTIR and XRD spectroscopy affirmed the loading of BBR in GNPs. The prepared BBR-GNPs exhibited a mean particle size of 215.4 ± 54.32 nm and a zeta potential of +22.6 ± 4.48 mV, as determined by dynamic light scattering (DLS), with an encapsulation efficiency of 72.5%. Scanning electron…
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Taxonomy
TopicsBerberine and alkaloids research · Nanoparticle-Based Drug Delivery · Andrographolide Research and Applications