# The new frontier in assisted reproduction: Consumer Desire vs. Regulatory and Ethical Precaution in AI-assisted Polygenic Embryo Screening

**Authors:** Aviad Raz, Aurélie Halsband, Robert Langner, Shiri Shkedi-Rafid

PMC · DOI: 10.1038/s44319-025-00668-2 · 2025-12-10

## TL;DR

AI-assisted polygenic embryo screening in IVF raises ethical and regulatory questions across different national contexts.

## Contribution

The paper introduces AI-assisted polygenic embryo screening and analyzes its ethical implications in three distinct national frameworks.

## Key findings

- AI-assisted screening can predict implantation success and disease risks in embryos.
- Germany, Israel, and the US show contrasting regulatory and ethical responses to the technology.
- Consumer desire for the technology conflicts with legal and ethical caution in some regions.

## Abstract

AI-assisted polygenic embryo screening is a new technology to predict embryonic implantation, disease risk and non-clinical traits for IVF embryos. To highlight its social and ethical implications, we locate it within the national landscapes of Germany’s legal caution, Israel’s techno-enthusiasm and US market liberalism.

## Full-text entities

- **Diseases:** cardiovascular disease (MESH:D002318), diabetes (MESH:D003920), Cystic Fibrosis (MESH:D003550), Duchenne Muscular Dystrophy (MESH:D020388), fetal anomaly (MESH:D000013), Down syndrome (MESH:D004314), Tay-Sachs (MESH:D013661), genetic disease (MESH:D030342), IVF (MESH:C566179), PGT (MESH:D013736), cancer (MESH:D009369)
- **Chemicals:** PES (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12852876/full.md

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Source: https://tomesphere.com/paper/PMC12852876