Different fatty acid patterns in serum in patients with various thyroid diseases
Martyna Lukasiewicz, Agata Zwara, Monika Czapiewska, Natalia Koc, Jan Opalko, Agata Janczy, Adriana Mika, Andrzej Hellmann
TL;DR
This study found distinct fatty acid patterns in patients with thyroid diseases, suggesting potential diagnostic biomarkers and metabolic insights.
Contribution
The study identifies specific fatty acid alterations in thyroid disorders, offering new diagnostic potential and metabolic understanding.
Findings
Levels of n-3 polyunsaturated fatty acids (ALA, EPA, DHA) were reduced in Hashimoto’s thyroiditis compared to healthy controls.
Certain fatty acids showed high AUC values in ROC analysis, indicating potential as diagnostic biomarkers for thyroid diseases.
Metabolite set enrichment analysis revealed disrupted pathways in α-linolenic and linoleic acid metabolism and β-oxidation.
Abstract
Thyroid diseases and obesity are major health issues in the 21st century. While fatty acids (FAs) are known to influence various conditions, their role in thyroid disorders remains unclear. This study investigated FA profiles in patients with thyroid diseases to assess their diagnostic potential. From 891 patients treated at the Thyroid Cancer Center of the Medical University of Gdansk (2021–2024), 173 were selected for FA analysis using gas chromatography-mass spectrometry. Receiver operating characteristic (ROC) analysis evaluated the predictive value of individual FAs, and metabolite set enrichment analysis (MSEA) identified changes in FA metabolism. Results showed significant alterations in FA profiles among thyroid disease patients. Notably, levels of specific n-3 polyunsaturated FAs (ALA, EPA, DHA) were reduced in Hashimoto’s thyroiditis (HT) compared to healthy controls, despite…
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Taxonomy
TopicsMetabolomics and Mass Spectrometry Studies · Fatty Acid Research and Health · Nutritional Studies and Diet