# Enhanced feature dynamic fusion gated UNet for robust retinal vessel segmentation

**Authors:** Yang Yang, Yifeng Li, Jikui Wang, Haibo Zhou, Weihua Zhang, Xing Chen, Tianyun Luan, Wanting Liu, Dashi Ying

PMC · DOI: 10.1038/s41598-025-33694-0 · 2025-12-26

## TL;DR

This paper introduces a new deep learning model for accurately segmenting retinal vessels in images, especially in challenging areas like small vessels and lesions.

## Contribution

The novel EFDG-UNet model integrates dynamic fusion, global position modeling, and adaptive attention for improved retinal vessel segmentation.

## Key findings

- EFDG-UNet achieved an AUC of 0.9932 and F1-score of 0.8469 on the CHASE_DB1 dataset.
- The model outperformed baseline methods in low-contrast and complex vessel regions.
- It showed strong performance across multiple datasets including DRIVE and STARE.

## Abstract

This study proposes a Deep learning model, the Enhanced Feature Dynamic Fusion-Gated U-Net (EFDG-UNet), for retinal vessel segmentation. To address challenges in segmenting small vessels, handling lesion interference, and adapting to multi-scale structures, the model incorporates optimized feature fusion, dynamic selection, and global position modeling. The Feature Navigation Hub (FN-Hub) captures long-range dependencies across multiple encoder layers, improving multi-scale vessel segmentation. The Adaptive Gated Residual Block (AGRB) uses a dynamic gating mechanism to enhance feature selectivity in lesion areas and low-contrast scenarios. The Parallel Focused Attention Module (PFAM) optimizes channel and spatial information for fine-grained vessel features. Experimental validation on DRIVE, CHASE_DB1, and STARE datasets shows that EFDG-UNet achieves state-of-the-art performance, attaining an AUC of 0.9932 and F1-score of 0.8469 on CHASE_DB1, and an AUC of 0.9886 and F1-score of 0.8412 on DRIVE. The model shows improved performance in low-contrast regions and complex vessel structures compared to baseline methods.

## Full-text entities

- **Genes:** VEZF1 (vascular endothelial zinc finger 1) [NCBI Gene 7716] {aka CMD1OO, DB1, ZNF161}
- **Diseases:** cardiovascular diseases (MESH:D002318), retinal abnormalities (MESH:D012164), coronary artery disease (MESH:D003324), ocular and systemic diseases (MESH:D034721), stroke (MESH:D020521), sclerosis (MESH:D012598), chronic hypertension (MESH:D006973), hemorrhages (MESH:D006470)
- **Chemicals:** copper (MESH:D003300), silver (MESH:D012834), AGRB (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** SKL202502024JC — Homo sapiens (Human), Adult acute myelomonocytic leukemia, Cancer cell line (CVCL_IU60)

## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12852779/full.md

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Source: https://tomesphere.com/paper/PMC12852779