# Case Report: FIA plus venetoclax in a patient on hemodialysis

**Authors:** Jacob E. Herstein, Kayleigh R. Marx, J. Michael Savoy, Wei Ying Jen, Musa Yilmaz, Nicholas J. Short, Ghayas C. Issa, Farhad Ravandi, Tapan M. Kadia, Naval G. Daver, Courtney D. DiNardo

PMC · DOI: 10.3389/fonc.2025.1740357 · 2026-01-15

## TL;DR

A patient with kidney failure and leukemia successfully responded to a specific chemotherapy regimen.

## Contribution

This case report demonstrates the successful use of FIA plus venetoclax in a hemodialysis-dependent AML patient.

## Key findings

- A 65-year-old female on hemodialysis achieved complete remission with FIA plus venetoclax for AML.
- The regimen was safely administered despite challenges in patients with end-stage renal disease.
- Interdisciplinary coordination was essential for managing pharmacological and logistical barriers.

## Abstract

The safe and effective delivery of curative cytotoxic chemotherapy for acute myeloid leukemia (AML) in patients receiving intermittent hemodialysis (IHD) for end-stage renal disease (ESRD) remains a clinical challenge; pharmacological and logistical barriers necessitate close interdisciplinary coordination. In this case, we report a 65-year-old female patient with chronic ESRD on IHD and newly diagnosed AML who achieved complete remission (CR) after treatment with fludarabine, idarubicin, and cytarabine plus venetoclax (i.e., FIA + venetoclax).

## Linked entities

- **Chemicals:** fludarabine (PubChem CID 657237), idarubicin (PubChem CID 42890), cytarabine (PubChem CID 6253), venetoclax (PubChem CID 49846579)
- **Diseases:** acute myeloid leukemia (MONDO:0015667), end-stage renal disease (MONDO:0004375)

## Full-text entities

- **Diseases:** AML (MESH:D015470), ESRD (MESH:D007676)
- **Chemicals:** idarubicin (MESH:D015255), cytarabine (MESH:D003561), FIA (-), venetoclax (MESH:C579720), fludarabine (MESH:C024352)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12852021