# Recent Progress in Mechanoluminescence for Multi‐Dimensional Stress Monitoring

**Authors:** Xiuxia Yang, Ting Wang, Lei Zhao, Xuhui Xu

PMC · DOI: 10.1002/advs.202519938 · Advanced Science · 2025-12-08

## TL;DR

This paper reviews recent advances in mechanoluminescent materials for multi-dimensional stress sensing and visualization.

## Contribution

The paper systematically analyzes design principles and application scenarios for 0D to 3D stress sensing technologies.

## Key findings

- Material defect engineering and ion doping have improved ML material performance.
- Multi-dimensional stress visualization enables real-time, high-resolution stress monitoring.
- Applications span structural damage detection, biomechanics, and human-computer interfaces.

## Abstract

Mechanoluminescence (ML) materials with their unique stress‐to‐light conversion capability, have been driving the evolution of stress sensing technology from single‐point detection to multi‐dimensional imaging. Recent advances in material defect engineering, ion doping, and heterostructure design have significantly improved the luminosity, response kinetics, and environmental stability of ML materials. These enhancements have established a technical foundation for multimodal stress visualization across diverse application scenarios. To systematically analyse the stress response mechanism and visual behavior of materials across different spatial dimensions, this review offers in‐depth discussions on material design principles, device integration methods, and application scenarios for 0D, 1D, 2D, and 3D stress sensing technologies. It further proposes targeted solutions to common challenges in multi‐dimensional stress sensing, such as material performance, device integration synergy, and data processing. Finally, the development path of multi‐dimensional stress visualization technology will be looked forward with higher spatial resolution in intelligent diagnosis, biomechanics, and extreme environmental monitoring, providing a theoretical framework and technical support for multi‐dimensional stress visualization detection.

Multi‐dimensional stress visualization technology (0D point detection, 1D linear distribution, 2D planar imaging, 3D volume reconstruction) has become a focus of attention in the field of stress sensing. The transition from “points” to “multi‐dimensional spatial fields” facilitates real‐time, in situ, and high‐resolution visualization of stress distribution, thereby enabling applications in structural damage warning, biological tissue mechanics behavior analysis, and human‐computer interaction interfaces.

## Full-text entities

- **Genes:** CNOT8 (CCR4-NOT transcription complex subunit 8) [NCBI Gene 9337] {aka CAF1, CALIF, Caf1b, POP2, hCAF1}, Camk2a (calcium/calmodulin-dependent protein kinase II alpha) [NCBI Gene 12322] {aka CaMKII, mKIAA0968}, FOS (Fos proto-oncogene, AP-1 transcription factor subunit) [NCBI Gene 2353] {aka AP-1, C-FOS, p55}, Dntt (deoxynucleotidyltransferase, terminal) [NCBI Gene 21673] {aka Tdt}, Fos (Fos proto-oncogene, AP-1 transcription factor subunit) [NCBI Gene 14281] {aka D12Rfj1, c-fos, cFos}, FUS (FUS RNA binding protein) [NCBI Gene 2521] {aka ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS}
- **Diseases:** mobility limitations (MESH:D051346), CTS (MESH:D003387), autoimmune diseases (MESH:D001327), cancer metastasis (MESH:D009369), fatigue (MESH:D005221), neurological disorders (MESH:D009461)
- **Chemicals:** sugar (MESH:D000073893), PVA (MESH:C063253), fluoride (MESH:D005459), salt (MESH:D012492), Ce (MESH:D002563), TiO2 (MESH:C009495), DPPC (MESH:D015060), Cs+ (MESH:D002586), nitrogen (MESH:D009584), Eu (MESH:D005063), MgO (MESH:D008277), S (MESH:D013455), silicone (MESH:D012828), Zn (MESH:D015032), biotin (MESH:D001710), citrate (MESH:D019343), Gly (MESH:D005998), boron (MESH:D001895), dUTP (MESH:C027078), LaF3 (MESH:C083668), ZrO2 (MESH:C028541), Co@ZnS (-), acrylic resin (MESH:D000180), SiO2 (MESH:D012822), Al2O3 (MESH:D000537), Y (MESH:D015019), oxygen (MESH:D010100), graphite (MESH:D006108), MgF2 (MESH:C031288), Cu (MESH:D003300), ROS (MESH:D017382), Si (MESH:D012825), PDMS (MESH:C013830), lanthanide (MESH:D028581), CNT (MESH:D037742), oxide (MESH:D010087), polymer (MESH:D011108), R837 (MESH:D000077271), alcohol (MESH:D000438), Yb2+ (MESH:C002989), PMMA (MESH:D019904), polyurethane (MESH:D011140), Dy (MESH:D004419), NaCl (MESH:D012965), water (MESH:D014867), In2O3 (MESH:C047711), epoxy (MESH:D004853), Mn (MESH:D008345), Al (MESH:D000535), Hematoxylin (MESH:D006416), Ag (MESH:D012834)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** T159C, E123T
- **Cell lines:** Balb/c — Mus musculus (Mouse), Spontaneously immortalized cell line (CVCL_0184), HeLa — Homo sapiens (Human), Human papillomavirus-related endocervical adenocarcinoma, Cancer cell line (CVCL_0030)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12849858/full.md

## Figures

16 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12849858/full.md

## References

92 references — full list in the complete paper: https://tomesphere.com/paper/PMC12849858/full.md

---
Source: https://tomesphere.com/paper/PMC12849858