# Medial femoral condyle free flap for reconstructions of medication related osteonecrosis of the jaw

**Authors:** Derek C. Wenger, Caleb W. Brown, Phillip L. Nichols, Hannah Tan, Jeremy M. Powers

PMC · DOI: 10.1080/23320885.2026.2619311 · Case Reports in Plastic Surgery & Hand Surgery · 2026-01-27

## TL;DR

A 57-year-old woman with jaw osteonecrosis due to cancer treatment was successfully treated with a specific type of tissue flap.

## Contribution

The study presents a successful case of using a medial femoral condylar free flap for MRONJ reconstruction.

## Key findings

- The patient recovered without complications after MFC free flap surgery.
- Normal jaw function was maintained at two-year follow-up.
- MFC free flap is a viable option for small mandibular defects in MRONJ patients.

## Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a rare complication of antiresorptive therapy that may require free tissue reconstruction. A 57-year-old woman with metastatic breast cancer developed refractory mandibular MRONJ after intravenous zoledronic acid and underwent reconstruction with a medial femoral condylar (MFC) free flap. She recovered without complications and maintained normal function at two-year follow-up. This case supports the MFC free flap as a viable option for small, partial-thickness mandibular defects in selected patients with MRONJ.

## Linked entities

- **Chemicals:** zoledronic acid (PubChem CID 68740)
- **Diseases:** osteonecrosis of the jaw (MONDO:0018378)

## Full-text entities

- **Diseases:** mandibular (MESH:D008338), breast cancer (MESH:D001943), osteonecrosis of the jaw (MESH:D059266)
- **Chemicals:** zoledronic acid (MESH:D000077211)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12849800/full.md

## References

35 references — full list in the complete paper: https://tomesphere.com/paper/PMC12849800/full.md

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Source: https://tomesphere.com/paper/PMC12849800