# Impact of Bariatric Surgery Type on Adipokines, Myokines, and Hepatokines: An 18-Month Prospective, Observational, Open-Label Study

## TL;DR

This study compares how three types of bariatric surgery affect body weight and hormone levels related to fat, muscle, and liver function over 18 months.

## Contribution

The study provides a detailed comparison of the effects of LSG, LGCP, and RYGB on adipokines, myokines, and hepatokines over an 18-month period.

## Key findings

- All bariatric surgeries significantly reduced body weight, BMI, and body fat percentage.
- Surgical procedures decreased fasting glucose, triglycerides, glycated hemoglobin, and leptin levels.
- Adiponectin levels increased significantly, while other biomarkers like ANGPTL3, ANGPTL4, ApoD, ApoE, FGF19, and FGF21 showed varied changes.

## Abstract

Bariatric surgery is the most effective way to treat obesity and improves obesity-related comorbidities. Laparoscopic sleeve gastrectomy (LSG) is one of several standard procedures, laparoscopic greater curvature plication (LGCP) is a relatively alternative bariatric technique, and Roux-en-Y gastric bypass (RYGB) is the gold standard of bariatric surgical procedures. The study included 95 patients who underwent three types of bariatric surgery. 48 of the subjects (28 women, 20 men) underwent LSG, 35 of the patients (21 women, 14 men) underwent LGCP and 12 of the subjects (8 women, 4 men) underwent RYGB. Anthropometry and biochemical parameters (glucose, glycated hemoglobin, cholesterol, HDL and LDL cholesterol, triglycerides, adiponectin, leptin, ANGPTL3, ANGPTL4, ApoD, ApoE, FGF19, and FGF21) were determined before and after 3, 6, 12 and 18 months of surgeries. All types of bariatric surgeries markedly decreased body weight, BMI, and percentage of body fat. The surgical procedures resulted in a decrease in mean fasting glucose, triglycerides, glycated hemoglobin concentrations and leptin concentrations in blood serum. On the other hand, plasma concentrations of adiponectin increased significantly. Different results were observed in serum ANGPTL3, ANGPTL4, ApoD, ApoE, FGF19, and FGF21 levels after all surgeries. All three types of bariatric surgery resulted in significant weight loss and changes in the levels of the measured parameters.