# Continuous and noninvasive respiratory effort monitoring: a narrative review of emerging techniques

**Authors:** J. Graßhoff, R. S. P. Warnaar, D. W. Donker, P. Rostalski, E. Oppersma

PMC · DOI: 10.1186/s40560-026-00852-z · Journal of Intensive Care · 2026-01-21

## TL;DR

This paper reviews new noninvasive methods for monitoring respiratory effort in patients on ventilators to prevent lung and diaphragm injuries.

## Contribution

The paper introduces and evaluates three emerging noninvasive techniques for continuous respiratory effort monitoring.

## Key findings

- Surface electromyography (sEMG) allows continuous monitoring of respiratory muscle activity via electrodes on the torso.
- Computational modeling can estimate patient-specific respiratory effort from ventilator waveforms.
- Diaphragm thickening fraction measured by ultrasound serves as a practical noninvasive surrogate for respiratory effort.

## Abstract

Ventilator-induced lung injury and diaphragm dysfunction are well-recognized complications of mechanical ventilation and commonly attributed to inadequate ventilator settings. Excessive or insufficient assistance and the patient’s own respiratory effort are increasingly acknowledged as important factors in the pathogenesis of these injuries. Therefore, monitoring respiratory effort at the bedside is a highly relevant strategy to identify and prevent potentially injurious breathing patterns. Esophageal manometry remains the reference standard for assessing respiratory effort, but its technical complexity limits routine clinical use. Placement and calibration of the esophageal balloon are time-consuming and require specific expertise. Moreover, the invasive nature of the procedure precludes visual confirmation and leads to uncertainty about correct positioning, reducing confidence in the validity of measurements. Innovative noninvasive and continuous monitoring techniques are emerging as more accessible and scalable alternatives, enabling assessment of respiratory effort without impacting so much on clinical workflow. This narrative review provides an in-depth overview of three noninvasive techniques that are reshaping continuous respiratory effort monitoring: (1) Surface electromyography (sEMG) now enables continuous monitoring of respiratory muscle activity and derivation of continuous effort estimation using electrodes placed on the torso of the patient. (2) Computational modeling offers dynamic, patient-specific effort estimation from ventilator waveforms. (3) Assessment of diaphragm thickening fraction, derived from high-resolution ultrasound, provides a straightforward surrogate for effort, driven by widely available acquisition devices. Together, these innovations promise to make respiratory muscle monitoring less labor-intensive and more clinically sustainable—paving the way for broader implementation of diaphragm-protective ventilation strategies in critical care.

## Full-text entities

- **Genes:** PTPRU (protein tyrosine phosphatase receptor type U) [NCBI Gene 10076] {aka FMI, PCP-2, PTP, PTP-J, PTP-PI, PTP-RO}, SEMG1 (semenogelin 1) [NCBI Gene 6406] {aka CT103, SEMG, SGI, dJ172H20.2}, PADI1 (peptidyl arginine deiminase 1) [NCBI Gene 29943] {aka HPAD10, PAD1, PDI, PDI1}
- **Diseases:** muscle (MESH:D019042), alveolar overdistension (MESH:D002282), edema (MESH:D004487), respiratory distress (MESH:D012128), occlusions (MESH:D001157), esophageal spasms (MESH:D015155), lung injury (MESH:D055370), diaphragm dysfunction (MESH:D065630), VILI (MESH:D055397), acute and chronic respiratory failure (MESH:D012131), MV (MESH:D053717), Critical (MESH:D016638)
- **Chemicals:** VVUQ (-), PS (MESH:D010758)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12849107/full.md

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Source: https://tomesphere.com/paper/PMC12849107