# Directed Dynamic Resolution of an Atropisomeric Silver Complex in Solution: Role of π–π Interactions

## TL;DR

Scientists used π–π interactions to control the stereochemistry of a silver complex in solution before crystallization.

## Contribution

A new method for dynamic resolution of atropisomers using π–π interactions in solution is introduced.

## Key findings

- π–π interactions with borate anions stabilize one enantiomer of an atropisomeric silver complex.
- NMR shows restricted dynamics and conformational locking before crystallization.
- Highly crystalline salts with resolved stereochemistry are obtained.

## Abstract

We report a directed
dynamic resolution process for an
atropisomeric
[Ag­(NHC)2]+ complex, where stereochemical control
is achieved through enantiomeric interconversion in solution before
crystallization. Unlike conventional diastereomeric salt formation,
our approach shifts the restricted interconversion between R
a and S
a atropisomers,
allowing selective stabilization of one enantiomer via π–π
interactions with enantiopure binaphthalene-based borate anions in
solution. NMR spectroscopy reveals conformational locking and restricted
dynamics preceding crystallization, which captures the resolved stereochemistry
in highly crystalline salts. This study demonstrates that noncovalent
interactions effectively modulate molecular conformational dynamics
to achieve chiral resolution.