# Taraxacum officinale Seed Extract Inhibits HeLa Cell Migration at Sub-cytotoxic Concentrations

## TL;DR

Dandelion seed extract inhibits cancer cell movement without killing them, suggesting a new way to fight cancer.

## Contribution

The study reveals a specific anti-migratory effect of dandelion seed extract on HeLa cells independent of cytotoxicity.

## Key findings

- DSE reduced HeLa cell migration speed without significantly affecting cell viability.
- HDF cells showed no significant migration change at low DSE concentrations.
- Both cell lines showed decreased migration at 0.1 mg/mL DSE.

## Abstract

Dandelion seed extract exhibits potent anticancer activity in HeLa cells. HeLa viability decreased with increasing doses of DSE from 0 to 0.8 mg/mL, while HDF viability was not affected under similar conditions. DSE reduced HeLa cells’ migration speed between 0-0.050 mg/mL, while no significant effect was observed in HDF cells over the same range. Both cell lines exhibited a significant decrease in cell migration speed at 0.1 mg/mL. This data suggests that DSE treatment inhibits cell migration before it significantly reduces cell viability. It points to a specific anti-migratory effect independent of viability loss.