# University student wellbeing during COVID-19: associations with infection prevalence and social gathering restrictions in an observational study

**Authors:** Donald J. Noble, Charles L. Raison

PMC · DOI: 10.3389/fpsyt.2025.1641305 · Frontiers in Psychiatry · 2026-01-14

## TL;DR

University students' wellbeing dropped during the pandemic, with social isolation and infection levels affecting different mental health aspects.

## Contribution

This study distinguishes the effects of infection prevalence and social restrictions on student wellbeing during the pandemic.

## Key findings

- Subjective wellbeing declined in Fall 2020 and remained low through Spring 2022, with over 60% of students at-risk for poor wellbeing.
- Depression and anxiety peaked in Fall 2021, with 39.0% and 34.5% of students at-risk, respectively.
- Wellbeing improved after returning to in-person learning, with social restrictions linked to anhedonia and infection levels to acute anxiety.

## Abstract

The COVID-19 pandemic served as a global, uncontrolled social isolation experiment, with especially pernicious effects on the wellbeing of young adults. We sought to understand how the COVID-19 pandemic impacted the wellbeing of university undergraduate students, distinguishing between factors related to infection prevalence and those linked to social restriction.

277 total U.S. undergraduate students enrolled in a course on mental wellbeing and resilience that was offered once each year from 2020 to 2024. Students anonymously completed surveys assessing anxiety, depression, and subjective wellbeing on a weekly basis. These behavioral data were aggregated and investigated for associations with local COVID-19 case levels and a university social gathering meter.

Subjective wellbeing declined a few months into the COVID-19 pandemic in Fall 2020, remaining low in Fall 2021 and Spring 2022, with 63.7% of students at-risk for poor wellbeing over these three semesters based on the standard cutoff. Depression and anxiety peaked during Fall 2021 with 39.0% and 34.5% of students at-risk for anxiety and depressive disorders, respectively. Wellbeing gradually improved following the return to in-person learning in mid-Spring 2022. Over all five semesters, survey questions reflecting anhedonia associated with social gathering restrictions whereas questions assessing acute anxiety associated with local COVID-19 case levels.

Our findings highlight the negative impact of the COVID-19 pandemic on university student wellbeing and suggest that COVID-19 infection prevalence and associated social isolation measures may have uniquely influenced different aspects of wellbeing. More research is needed to assess causality, while accounting for other potential socio-economic and academic factors.

## Linked entities

- **Diseases:** COVID-19 (MONDO:0100096)

## Full-text entities

- **Diseases:** anhedonia (MESH:D059445), Depression (MESH:D003866), COVID-19 (MESH:D000086382), anxiety (MESH:D001007), infection (MESH:D007239)

## Full text

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## Figures

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## References

47 references — full list in the complete paper: https://tomesphere.com/paper/PMC12848539/full.md

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Source: https://tomesphere.com/paper/PMC12848539