# Global perspectives on Klebsiella epidemiology and biology: conference report on the KLEBS 2024 symposium **Authors:** Chiara Crestani, Kelly L. Wyres, Jabir Abdulahi, Archana Angrup, William Boateng, Chanté Brand, Arsène G. Djoko Nono, Teca C. Galvao, Devarshi Gajjar, Francisco Gonzalez-Espinosa, Mateusz Hasso-Agopsowicz, Yogesh Hooda, Sanika M. Kulkarni, Rudzani Mashau, Richael O. Mills, Geetha Nagaraj, Issa Ndiaye, Courtney P. Olwagen, Lala Rafetrarivony, Andriniaina Rakotondrasoa, Denasha L. Reddy, Varun Shamanna, Liliwe Shuping, Talyta Soares do Nascimento, Blessing K. A. Tabi, Lara Van der Merwe, Kathryn E. Holt, Sylvain Brisse PMC · DOI: 10.1038/s44259-025-00175-3 · npj Antimicrobials and Resistance · 2026-01-27 ## TL;DR This report summarizes a conference on Klebsiella biology and epidemiology, highlighting research on public health, genomics, and treatments. ## Contribution The paper provides a comprehensive overview of the inaugural KLEBS 2024 symposium's research and discussions. ## Key findings - The symposium covered topics from Klebsiella's fundamental biology to public health implications. - Presentations included genomics, host-pathogen interactions, and therapeutic strategies. - A conference recording is publicly available for further access. ## Abstract The inaugural Klebsiella Epidemiology and Biology Symposium (KLEBS) took place in November 20-22, 2024, at the Institut Pasteur in Paris. It covered a broad multidisciplinary range of topics from fundamental biology to public health aspects, including epidemiology and public health burden, One Health and clinical aspects, genomics, host-pathogen interactions, vaccines, and therapeutics. This report describes research presented during keynote presentations, plenary sessions and a panel discussion. A recording of the conference is available at: https://www.klebs-2024.conferences-pasteur.org/replay. ## Linked entities - **Species:** Klebsiella (taxon 570) ## Full-text entities - **Genes:** CMPK1 (cytidine/uridine monophosphate kinase 1) [NCBI Gene 51727] {aka CK, CMK, CMPK, UMK, UMP-CMPK, UMPK}, Nlrx1 (NLR family member X1) [NCBI Gene 315599] {aka RGD1311293}, IL10 (interleukin 10) [NCBI Gene 3586] {aka CSIF, GVHDS, IL-10, IL10A, TGIF}, Fubp1 (far upstream element (FUSE) binding protein 1) [NCBI Gene 51886] {aka 9530027K12Rik, D3Ertd330e, FBP, Fubp, Fubp4}, Crp (C-reactive protein, pentraxin-related) [NCBI Gene 12944], URI1 (URI1 prefoldin like chaperone) [NCBI Gene 8725] {aka C19orf2, NNX3, PPP1R19, RMP, URI}, Dnm1l (dynamin 1-like) [NCBI Gene 114114] {aka DLP1, Dnml1, Drp1}, IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, blaNDM-1 [NCBI Gene 17373266], Nos3 (nitric oxide synthase 3) [NCBI Gene 24600] {aka eNos} - **Diseases:** IBD (MESH:D015212), neutrophilia (MESH:C563010), neonatal (MESH:D007232), Neonatal sepsis (MESH:D000071074), bloodstream infections (MESH:D018805), Infectious (MESH:D003141), urinary tract infections (MESH:D014552), infants (MESH:D063766), Bacterial-Diseases (MESH:D001424), AMR (MESH:D060467), Infection (MESH:D007239), Kpn pneumonia (MESH:D011014), nasal infection (MESH:D009668), inflammation (MESH:D007249), Klebsiella infections (MESH:D007710), neutropenic (MESH:D044504), mitochondrial fragmentation (MESH:D012892), liver abscesses (MESH:D008100), bacterial pneumonia (MESH:D018410), bacteremia (MESH:D016470), nosocomial infections (MESH:D003428), Disease (MESH:D004194), wound infection (MESH:D014946), malnourished (MESH:D044342), deaths (MESH:D003643), acquired (MESH:D003638), diabetes (MESH:D003920), respiratory infections (MESH:D012141) - **Chemicals:** cephalosporin (MESH:D002511), iron (MESH:D007501), tetracyclines (MESH:D013754), aminoglycosides (MESH:D000617), CDAP (-), sugar (MESH:D000073893), aerobactin (MESH:C031819), carbapenem (MESH:D015780), imipenem (MESH:D015378), calcium (MESH:D002118), O-antigen (MESH:D019081), cyclophosphamide (MESH:D003520), polysaccharide (MESH:D011134), LPS (MESH:D008070), alum (MESH:C041524), bile salts (MESH:D001647), ATP (MESH:D000255), penicillin (MESH:D010406), sulphonamides (MESH:D013449) - **Species:** Gallus gallus (bantam, species) [taxon 9031], Streptomyces sp. t14 (species) [taxon 1828143], Klebsiella (genus) [taxon 570], Acinetobacter baumannii (species) [taxon 470], Human immunodeficiency virus (species) [taxon 12721], Human immunodeficiency virus 1 (no rank) [taxon 11676], Galleria mellonella (greater wax moth, species) [taxon 7137], Klebsiella variicola (species) [taxon 244366], Raoultella [taxon 160674], Oryctolagus cuniculus (domestic rabbit, species) [taxon 9986], Klebsiella pneumoniae (species) [taxon 573], Shewanella glacialipiscicola (species) [taxon 614069], Homo sapiens (human, species) [taxon 9606], Sus scrofa (pig, species) [taxon 9823], Mus musculus (house mouse, species) [taxon 10090], Bacteriophage sp. (species) [taxon 38018], Rattus norvegicus (brown rat, species) [taxon 10116], Bos taurus (bovine, species) [taxon 9913] - **Cell lines:** K64 — Mus musculus (Mouse), Hepatocellular carcinoma of the mouse, Cancer cell line (CVCL_5770), J774 — Mus musculus (Mouse), Mouse reticulum cell sarcoma, Cancer cell line (CVCL_4692) ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12847830/full.md ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12847830/full.md ## References 5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12847830/full.md --- Source: https://tomesphere.com/paper/PMC12847830