# A Review of the Long-Term Cardiovascular Consequences of Hypertensive Disorders of Pregnancy

**Authors:** Ahmed Rudwan, Leena Saeed, Layla Mahir, Aya Husameldin, Ammar Ahmed, Qubaa A Elzubair, Waad Ahmed, Muqadsa Malik, Enaam Rudwan

PMC · DOI: 10.7759/cureus.100288 · Cureus · 2025-12-28

## TL;DR

This paper reviews how high blood pressure during pregnancy can lead to long-term heart and blood vessel problems for mothers.

## Contribution

The paper highlights the long-term cardiovascular risks of hypertensive disorders of pregnancy and emphasizes the need for better postpartum monitoring.

## Key findings

- Women with HDP have higher risks of cardiovascular disease and chronic kidney disease.
- Early aspirin and lifestyle changes help, but adherence is low.
- Postpartum monitoring is underused despite its importance.

## Abstract

Hypertensive disorders of pregnancy (HDP) are a major worldwide issue, affecting 5-10% of pregnancies and causing feto-maternal mortality and morbidity. It includes chronic, gestational hypertension, preeclampsia, and chronic hypertension with preeclampsia. The underlying pathophysiology includes aberrant placental perfusion, angiogenic imbalance, endothelial dysfunction, and hereditary susceptibility. Women with HDP face a markedly increased risk of cardiovascular disease, chronic renal disease, and metabolic syndrome, with larger connections than those with gestational diabetes. Measures such as early aspirin prophylaxis, lifestyle modifications, and prompt antihypertensive therapy are beneficial, but adherence remains low. Postpartum monitoring is generally underused, despite its importance in reducing future cardiovascular risk. Addressing these gaps is critical for lowering maternal mortality, avoiding recurring problems, and improving health outcomes.

## Linked entities

- **Diseases:** cardiovascular disease (MONDO:0004995), chronic renal disease (MONDO:0005300), metabolic syndrome (MONDO:0000816)

## Full-text entities

- **Diseases:** metabolic syndrome (MESH:D024821), gestational diabetes (MESH:D016640), HDP (MESH:D046110), cardiovascular disease (MESH:D002318), chronic renal disease (MESH:D051436), hypertension (MESH:D006973), preeclampsia (MESH:D011225)
- **Chemicals:** aspirin (MESH:D001241)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

41 references — full list in the complete paper: https://tomesphere.com/paper/PMC12847464/full.md

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Source: https://tomesphere.com/paper/PMC12847464