# Commentary: Trehalose alleviates nephropathy in focal segmental glomerulosclerosis via the upregulation of the WT-1/EZH2 pathway

**Authors:** Fei Tian

PMC · DOI: 10.3389/fphar.2026.1761856 · Frontiers in Pharmacology · 2026-01-14

## Full-text entities

- **Genes:** EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) [NCBI Gene 2146] {aka ENX-1, ENX1, EZH2b, KMT6, KMT6A, WVS}, WT1 (WT1 transcription factor) [NCBI Gene 7490] {aka AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1}
- **Diseases:** glomerulosclerosis (MESH:D005921), nephropathy (MESH:D007674)
- **Chemicals:** Trehalose (MESH:D014199)

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## References

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Source: https://tomesphere.com/paper/PMC12847272