# Unifying Summary Statistic Selection for Approximate Bayesian Computation

**Authors:** Till Hoffmann, Jukka-Pekka Onnela

PMC · DOI: 10.1007/s11222-025-10808-2 · Statistics and Computing · 2026-01-27

## TL;DR

This paper introduces a unifying approach for selecting summary statistics in approximate Bayesian computation, improving inference efficiency and accuracy across various models.

## Contribution

The paper proposes minimizing expected posterior entropy as a unifying principle for summary statistic selection in likelihood-free inference.

## Key findings

- Minimizing EPE subsumes many existing methods for summary statistic selection.
- EPE-minimizing summaries can outperform likelihood-based approaches in some cases.
- The method was successfully tested on diverse models including population genetics and dynamic networks.

## Abstract

Extracting low-dimensional summary statistics from large datasets is essential for efficient (likelihood-free) inference. We characterize three different classes of summaries and demonstrate their importance for correctly analyzing dimensionality reduction algorithms. We demonstrate that minimizing the expected posterior entropy (EPE) under the prior predictive distribution of the model provides a unifying principle that subsumes many existing methods; they are shown to be equivalent to, or special or limiting cases of, minimizing the EPE. We offer a unifying framework for obtaining informative summaries and propose a practical method using conditional density estimation to learn high-fidelity summaries automatically. We evaluate this approach on diverse problems, including a challenging benchmark model with a multi-modal posterior, a population genetics model, and a dynamic network model of growing trees. The results show that EPE-minimizing summaries can lead to posterior inference that is competitive with, and in some cases superior to, dedicated likelihood-based approaches, providing a powerful and general tool for practitioners.

## Full-text entities

- **Genes:** KL (klotho) [NCBI Gene 9365] {aka HFTC3, KLA}, ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)) [NCBI Gene 10058] {aka ABC, LAN, MTABC3, PRP, umat}, NT5M (5',3'-nucleotidase, mitochondrial) [NCBI Gene 56953] {aka dNT-2, dNT2, mdN}
- **Diseases:** CPE (MESH:D020763)

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12847231/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12847231/full.md

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Source: https://tomesphere.com/paper/PMC12847231