# Caffeine ingestion before exercise improves prolonged intermittent-sprint performance of team-sport athletes in normobaric hypoxia

**Authors:** Wei Li, Zuojun Cao, Jie Chang, Ruiguo Xue, Jue Liu, Li Guo, Yinhang Cao, Olivier Girard

PMC · DOI: 10.3389/fnut.2025.1717009 · Frontiers in Nutrition · 2026-01-14

## TL;DR

Caffeine improves team-sport athletes' performance during high-intensity exercise in low-oxygen conditions.

## Contribution

Shows caffeine enhances intermittent-sprint performance in normobaric hypoxia for team-sport athletes.

## Key findings

- Caffeine increased total work done by 6.2% in the first half and 5.3% in the second half.
- Caffeine improved peak and mean power output during the test.
- Caffeine lowered perceived exertion and breathing difficulty in the second half.

## Abstract

To investigate whether caffeine ingestion before exercise enhances performance during a prolonged intermittent-sprint test (IST) under hypoxic conditions simulating team-sport activity.

In a randomized, double-blind, placebo-controlled crossover design, fifteen (five females) team-sport athletes (21 ± 2 years; peak oxygen uptake: 51.9 ± 3.4 ml/kg/min) completed two IST sessions in normobaric hypoxia (inspired oxygen fraction: 16.5 ± 0.2%), separated by 7 days. Sixty minutes before each session, participants ingested either 6 mg/kg caffeine or a placebo. The IST, performed on a cycle ergometer, consisted of two 40-min halves. Each half included twenty 2-min blocks, comprising an 8-s all-out sprint, 100 s of active recovery at 35% peak oxygen uptake, and 12 s of passive rest.

Total work done was significantly greater with caffeine, increasing by 6.2% in the first half (154 ± 26 vs. 145 ± 27 kJ) and a 5.3% increase in the second half (138 ± 20 vs. 132 ± 22 kJ) compared to placebo (all p < 0.05). Caffeine also significantly increased both peak and mean power output (all p < 0.05). Blood lactate concentrations were higher in both halves with caffeine, while ratings of perceived exertion and breathing difficulty were significantly lower in the second half compared to placebo (all p < 0.05).

A moderate dose of caffeine intake before exercise significantly enhances prolonged intermittent-sprint performance in competitive team-sport athletes under moderate normobaric hypoxia.

## Linked entities

- **Chemicals:** caffeine (PubChem CID 2519)

## Full-text entities

- **Diseases:** breathing difficulty (MESH:D004417), hypoxic (MESH:D002534), hypoxia (MESH:D000860)
- **Chemicals:** Blood lactate (-), oxygen (MESH:D010100), Caffeine (MESH:D002110)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12847040/full.md

## References

62 references — full list in the complete paper: https://tomesphere.com/paper/PMC12847040/full.md

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Source: https://tomesphere.com/paper/PMC12847040