# Ocular metastasis in breast cancer: management of clinical case reports and a literature review

**Authors:** Jizhuo Gao, Qian Cao, Yi Liu, Mengyao Huang, Man Li, Lingzhi Xu

PMC · DOI: 10.3389/fonc.2025.1605881 · Frontiers in Oncology · 2026-01-14

## TL;DR

This paper discusses rare breast cancer cases that spread to the eye, aiming to improve diagnosis and treatment for better patient outcomes.

## Contribution

The paper presents three clinical cases and a literature review to guide the management of breast cancer-related ocular metastasis.

## Key findings

- Ocular metastasis from breast cancer is rare and often asymptomatic, leading to potential misdiagnosis.
- The paper summarizes effective diagnostic methods and treatment strategies for managing ocular metastasis.
- Improved clinical awareness and standardized management can enhance patient survival and quality of life.

## Abstract

In recent years, the incidence of breast cancer (BC) and its distant metastases, including ocular metastasis (OM), has continued to rise. However, reports on BC-OM remain scarce. OM is rare and often asymptomatic. It can be easily masked by metastases in other organs, increasing the risk of misdiagnosis, and thus warrants greater clinical attention. In this paper, we describe three cases of BC-OM, review its epidemiological and clinical features, and summarize diagnostic methods and treatment strategies. Our aim is to provide a reference for clinical practice, support standardized management, and ultimately improve patient survival and quality of life (QoL).

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989)

## Full-text entities

- **Diseases:** OM (MESH:D009362), BC (MESH:D001943)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12846979/full.md

## References

57 references — full list in the complete paper: https://tomesphere.com/paper/PMC12846979/full.md

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Source: https://tomesphere.com/paper/PMC12846979