# Sex difference in parental risk of suicide attempt during and after pregnancy in Sweden

**Authors:** Yihui Yang, Emma Bränn, Emma Fransson, Krisztina D. László, Fang Fang, Fotios C. Papadopoulos, Unnur A. Valdimarsdóttir, Alkistis Skalkidou, Donghao Lu

PMC · DOI: 10.1038/s41562-025-02311-5 · Nature Human Behaviour · 2025-09-25

## TL;DR

A study in Sweden found that mothers have a lower risk of suicide attempts during and after pregnancy compared to fathers, reversing the usual sex difference seen in the general population.

## Contribution

This study provides new insights into sex differences in suicide risk among parents during and after pregnancy using nationwide data.

## Key findings

- Mothers had a significantly lower risk of suicide attempts during pregnancy and postpartum compared to fathers.
- Fathers showed a higher risk of suicide attempts in the later postpartum period compared to the early postpartum period.
- The sex difference in suicide risk reverses during and after pregnancy compared to the general population.

## Abstract

Whether the risks of maternal and paternal suicide attempt during and after pregnancy differ remains unclear. Here, in this nationwide register-based study in Sweden (2,196,276 pregnancies), we defined the year before conception, pregnancy and the year after birth and estimated week-specific incidence rate ratios (IRRs). We identified 7,469 (1.39 per 1,000 person-years) suicide attempts among mothers and 8,338 (1.62 per 1,000 person-years) among fathers. Compared with the corresponding week in the preconception period, mothers had a lower risk of suicide attempt during and after pregnancy (with the lowest IRR of 0.14 (0.11–0.17) at first week postpartum); fathers’ risk of suicide attempt remained largely stable before childbirth, but a lower risk was observed during the first 10 postpartum weeks (IRRs ranging from 0.69 (0.58–0.81) to 0.91 (0.84–0.99)), followed by a higher risk in the later postpartum period (IRRs ranging from 1.10 (1.01–1.21) to 1.72 (1.33–2.24)). Compared with fathers, mothers had a lower risk of suicide attempt during and after pregnancy (for example, IRR of 0.22 (0.18–0.28) at first week postpartum). Compared with the general population, the sex difference of suicide attempt is reversed during and after pregnancy, suggesting pregnancy or childbirth may have a more pronounced association with suicide attempt among mothers than fathers.

A Swedish study examined whether the risks of maternal and paternal suicide attempt differ during and after pregnancy and found a reversed sex difference in risk of suicide attempt during and after pregnancy compared with the general population.

## Full-text entities

- **Diseases:** death (MESH:D003643), postpartum depression (MESH:D019052), poisoning (MESH:D011041), depression (MESH:D003866), psychiatric (MESH:D001523), stillbirths (MESH:D050497)
- **Chemicals:** progesterone (MESH:D011374)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12846918/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12846918/full.md

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Source: https://tomesphere.com/paper/PMC12846918