# Challenges in the Vaccination of HIV-Infected Individuals

## TL;DR

This review discusses the challenges of vaccinating people with HIV due to their diverse health conditions and treatment statuses.

## Contribution

The paper provides an updated overview of vaccine recommendations and immunotherapeutic strategies for HIV-infected individuals.

## Key findings

- Antiviral treatment success significantly affects vaccination outcomes in people living with HIV.
- Current vaccine recommendations for PLWH consider their treatment status and immune health.
- Immunotherapeutic strategies aim to improve immune control in HIV-infected individuals.

## Abstract

Vaccination of people living with an HIV infection (PLWH) remains a worldwide challenge. The reason is the heterogeneity of this group that comprises people with and without highly active retroviral treatment and varying degrees of immunosuppression. In this review, we (i) highlight the impact of antiviral treatment success on vaccination outcomes, (ii) describe the current vaccine recommendations for PLWH, and (iii) summarize immunotherapeutic strategies for improved HIV immune control.