Benzimidazole-Quinoline Hybrids: Synthesis and Antimicrobial Properties
Maria Marinescu
TL;DR
This paper reviews the synthesis and antimicrobial properties of benzimidazole-quinoline hybrid compounds, highlighting their potential as effective and low-toxicity antimicrobial agents.
Contribution
The paper provides a comprehensive review of recent synthetic methods and antimicrobial activities of benzimidazole-quinoline hybrids.
Findings
Hybrids with halogen substitution and specific linker structures show enhanced antimicrobial activity.
Some hybrids exhibit low MICs (1–8 µg/mL) and low cytotoxicity, indicating strong antimicrobial potential.
Incorporating a five-membered heterocycle improves the therapeutic properties of these hybrids.
Abstract
Background: Heterocyclic compounds are particularly important in medicinal chemistry. With a range of therapeutic uses, benzimidazoles and quinolines are both key heterocycles in medicinal chemistry. A number of hybrid heterocyclic compounds have been reported in recent years because they typically have better therapeutic properties than single heterocyclic rings. Methods: A literature search was conducted across relevant scientific literature from peer-reviewed sources, using keywords, including “benzimidazole”, “quinoline”, “benzimidazole-quinoline hybrids”, “antibacterial”, “antifungal”, “antimalarial” and “hybrid complexes”. Results: This review summarizes the synthetic methodologies for benzimidazole–quinoline hybrids, benzimidazole– quinolinones, and benzimidazole–quinoline metal complexes, along with their antimicrobial and antimalarial activities and the reported…
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Taxonomy
TopicsSynthesis and biological activity · Multicomponent Synthesis of Heterocycles · Synthesis and bioactivity of alkaloids