Effects of Mixed Fruits and Berries on Ameliorating Gut Microbiota and Hepatic Alterations Induced by Cafeteria Diet
Rawan Al Hazaimeh, Louis Shackelford, Judith Boateng
TL;DR
This study shows that mixed fruits and berries can improve gut health and reduce liver issues in rats fed a cafeteria diet, suggesting a potential dietary solution for metabolic syndrome.
Contribution
The study introduces mixed fruits and berries as an effective dietary intervention to restore gut microbiota and liver health disrupted by a cafeteria diet in adolescent rats.
Findings
MFB supplementation reduced hepatic lipid accumulation and inflammation in cafeteria diet-fed rats.
MFB restored beneficial gut bacteria like Bifidobacterium pseudolongum and Akkermansia muciniphila.
MFB improved gut microbiota diversity and SCFA production, enhancing intestinal barrier integrity.
Abstract
Background/Objectives: The study investigated the potential of mixed fruits and berries (MFB) as a dietary intervention to mitigate cafeteria (CAF) diet-induced gut microbiome dysbiosis and hepatic dysfunction associated with metabolic syndrome and steatohepatitis (MASH) in an adolescent rat model. Methods: Forty-eight adolescent male Sprague-Dawley rats (n = 3 cages per group (two rats per cage)) were divided into eight experimental groups, where NC received the normal AIN-93G basal diet, PC received the CAF diet and normal AIN-93G basal diet, T1 and T2 received MFB supplementation (3% and 6% levels) without CAF exposure, P1 and P2 received a MFB (3% and 6% levels) supplementation initiated at the onset of CAF feeding, and I1 and I2 received MFB supplementation initiated 2 weeks after CAF feeding. After 6 weeks, cecal 16S rRNA, hepatic histopathology, Oil Red O staining, and metabolic…
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Taxonomy
TopicsLiver Disease Diagnosis and Treatment · Food composition and properties · Gut microbiota and health