# Vitamin Supplementation in Sports: A Decade of Evidence-Based Insights

**Authors:** Magdalena Wiacek, Emilia Nowak, Piotr Lipka, Remigiusz Denda, Igor Z. Zubrzycki

PMC · DOI: 10.3390/nu18020213 · 2026-01-09

## TL;DR

This review examines how vitamin supplementation affects athletes, emphasizing the need for personalized strategies based on sport type and individual needs.

## Contribution

The paper provides updated, evidence-based insights on vitamin supplementation for athletes over the past decade.

## Key findings

- Vitamin D deficiency is common in athletes, especially in indoor sports and winter months.
- Antioxidant vitamins C and E reduce oxidative stress but may hinder adaptive responses at high doses.
- B-complex vitamins support energy metabolism and red blood cell synthesis in athletes.

## Abstract

Background: Vitamins are micronutrients involved in multiple physiological processes critical for athletic performance. Because athletes are often exposed to increased oxidative stress, higher metabolic turnover, and greater nutritional demands, which can potentially lead to deficiencies in vitamins, understanding vitamin supplementation as a function of sport discipline is of fundamental importance. Methods: This narrative review synthesizes research findings from the past decade, supplemented with earlier studies where necessary, focusing on vitamins A, C, D, E, and the B-complex vitamins. Peer-reviewed literature was evaluated for evidence on the prevalence of deficiencies in athletes, physiological mechanisms, supplementation strategies, and their effects on performance, injury prevention, and recovery. Results: Vitamin D deficiency is highly prevalent among athletes, particularly in indoor sports and during the winter months. Supplementation has been shown to improve musculoskeletal health and potentially reduce injury risk. The antioxidant vitamins C and E can attenuate exercise-induced oxidative stress and muscle damage; however, excessive intake may impair adaptive responses such as mitochondrial biogenesis and protein synthesis. Vitamin A contributes to immune modulation, metabolic regulation, and mitochondrial function, while B-complex vitamins support energy metabolism and red blood cell synthesis. Conclusions: Vitamin supplementation in athletes should be individualized, targeting confirmed deficiencies and tailored to sport-specific demands, age, sex, and training intensity. Dietary optimization should remain the primary strategy, with supplementation serving as an adjunct when intake is insufficient. Further high-quality, sport-specific, and long-term studies are needed to establish clear dosing guidelines and to assess the balance between performance benefits and potential risks associated with over-supplementation.

## Linked entities

- **Chemicals:** vitamin A (PubChem CID 445354), vitamin C (PubChem CID 54670067), vitamin E (PubChem CID 14985)

## Full-text entities

- **Diseases:** deficiencies (MESH:D007153), injury (MESH:D014947), Vitamin D deficiency (MESH:D014808), muscle damage (MESH:D009133)
- **Chemicals:** Vitamin A (MESH:D014801), B-complex vitamins (-)

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12845069/full.md

---
Source: https://tomesphere.com/paper/PMC12845069