Formulation and Evaluation of Alginate-Based Hydrogel Membranes Loaded with Colistin for Effective Management of Multidrug-Resistant Wound Infections
Nizar Muhammad, Syed Sikandar Shah, Ashfaq Ahmad Shah Bukhari, Jamil Ahmed, Shahnaz Usman, Shujaat Ali Khan, Aftab Alam, Syed Arman Rabbani, Junaid Asghar
TL;DR
This study creates and tests hydrogel wound dressings loaded with colistin to manage multidrug-resistant infections, showing promising antibacterial effects.
Contribution
A novel alginate-based hydrogel membrane formulation with colistin for wound infection management is developed and evaluated.
Findings
Hydrogel membranes showed suitable physical properties and compatibility for wound dressing applications.
Both membrane groups exhibited antibacterial activity against multidrug-resistant Pseudomonas aeruginosa.
Drug release was not significantly different across various media.
Abstract
Background: Combating antimicrobial resistance and developing dressings that match all aspects of wound healing will always be challenging. Methods: In this study, hydrogel membranes composed of sodium alginate (SA), polyvinyl alcohol (PVA), and Pluronic-f-127 (F-127) loaded with colistin (C) were formulated. The formulations were divided into two groups: group 1 (SA-PVA-C) and group 2 (SA-PVA-F127-C). Results: The membranes were characterized using multiple techniques, which confirmed component compatibility, physical cross-linking, an amorphous structure, and suitable surface morphology with acceptable porosity. Mechanical testing showed that both groups were suitable for wound-dressing applications. Differences in drug release across media (water, normal saline, and phosphate) were non-significant (p value > 0.05). Drug-loaded membranes (n = 3) from both groups showed antibacterial…
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Taxonomy
TopicsWound Healing and Treatments · Hydrogels: synthesis, properties, applications · Graphene and Nanomaterials Applications