Effective Non-Invasive Delivery of Epigenetic Drugs Using Functionalized Accessory Unit Conjugates
Toshihiko Tashima
TL;DR
This paper reviews how attaching special helper units to epigenetic drugs can improve their delivery into cells for better cancer treatment.
Contribution
The paper introduces the use of functionalized accessory unit conjugates to enhance non-invasive delivery of epigenetic drugs.
Findings
Functionalized accessory units can improve membrane permeability and stability of epigenetic drugs.
These conjugates may enhance biodistribution and targeting of drugs to specific cells.
The review highlights potential advantages of this delivery method for epigenetic therapies.
Abstract
Epigenetics involves heritable changes in gene expression—such as DNA methylation (5-methylcytosine; 5mC), histone modifications, and regulation by non-coding RNAs at the mRNA translation level—without altering the underlying DNA sequence. As targeting these mechanisms enables intervention at the root cause of disease rather than the symptoms alone, epigenetics has become a rapidly advancing field in pharmaceutical sciences. Various epigenetic modulators, including histone deacetylase (HDAC) inhibitors, histone acetyltransferase (HAT) inhibitors, DNA methyltransferase (DNMT) inhibitors, and microRNAs (miRNAs), have been developed, and some have already been approved for cancer therapy. However, these agents often face significant challenges such as poor membrane permeability, enzymatic instability, and suboptimal biodistribution. Incorporating functionalized accessory units—serving as…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsRNA Interference and Gene Delivery · Histone Deacetylase Inhibitors Research · Epigenetics and DNA Methylation