# Cycloruthenated Imines: A Step into the Nanomolar Region

## TL;DR

Scientists developed new antiproliferative compounds with nanomolar effectiveness and good selectivity for cancer treatment.

## Contribution

A new series of cycloruthenated imines with nanomolar antiproliferative activity and high selectivity was developed and characterized.

## Key findings

- The compounds showed nanomolar IC50 values against A2780 and HEK293 cell lines.
- They exhibited a selectivity index of up to 2.5, indicating cancer cell selectivity.
- The compounds were fully characterized using UV-Vis, X-ray, NMR, HRMS, and cyclic voltammetry.

## Abstract

A new series of promising and easily accessible antiproliferative agents based on cycloruthenated imines of benzene and thiophene carbaldehydes has been developed and fully characterized using UV-Vis spectroscopy, X-ray diffraction, NMR, HRMS, and cyclic voltammetry. The biological activity of these compounds was tested against A2780, cisplatin-resistant A2780, and HEK293 cell lines, and they exhibited nanomolar IC50 values. They also showed a selectivity index of up to 2.5, indicating their potential as promising antiproliferative compounds.