The Influence of Mask Modification on Microneedle Strength in Deep X-Ray Lithography
Jie Wang, Yigui Li, Lin Du
TL;DR
This paper explores how modifying mask shapes in X-ray lithography affects the strength and performance of microneedles used for drug delivery and blood collection.
Contribution
The study introduces a novel approach to enhancing microneedle strength and flow rate through photomask shape modification and hole position optimization.
Findings
Modifying the shape of the photomask increases microneedle strength and compensates for exposure-related shortcomings.
Placing holes away from the microneedle tip center improves flow rate.
A 30 μm horizontal and 50 μm vertical offset from the tip center provides optimal hole alignment for strength and sharpness.
Abstract
Hollow microneedle arrays of different shapes were prepared for blood collection and precise drug delivery. This microneedle array was investigated using shape modification and hole position optimization, and different approaches to increase the strength of the microneedles and hole alignment were analyzed. Firstly, solid-tip microneedles were prepared using deep X-ray lithography, and an approach to increase the strength of microneedles by modifying the shape of the photomask was examined. Secondly, photomasks with holes in different positions were designed, and the exposure was aligned at different hole positions. Finally, the maximum stress and minimum displacement were analyzed using ANSYS 10.0 simulation software, while the proof-of-strength properties were accomplished by inserting microneedles into a polyimide film. The experimental results show that the modification of the shape…
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Taxonomy
TopicsAdvancements in Transdermal Drug Delivery · Photodynamic Therapy Research Studies · Neuroscience and Neural Engineering