# Straightforward Synthetic Approach to Aminoalcohols with 9-oxabicyclo[3.3.1]nonane or Cyclooctane Core via Nucleophilic Ring-Opening of Spirocyclic Bis(oxiranes)

## TL;DR

This paper presents a new method to synthesize aminoalcohols using ring-opening reactions of spirocyclic bis(oxiranes) with amines.

## Contribution

A straightforward, stereoselective synthesis of aminoalcohols with specific cyclic cores via nucleophilic ring-opening.

## Key findings

- Trans-isomer produces aminoalcohols with a 9-oxabicyclo[3.3.1]nonane core through a domino process.
- Cis-isomer yields aminosubstituted cis-cyclooctane-1,5-diols from independent oxirane reactions.
- LiClO4 activation enables use of various amines in the ring-opening process.

## Abstract

Nucleophilic ring-opening of bis(oxiranes), containing several reactive centers, can be used to elaborate straightforward atom-economy and stereoselective approaches to polyfunctionalized compounds. In the present work, ring-opening of cis- and trans-diastereomers of a spirocyclic bis(oxirane), containing a cyclooctane core (namely, 1,8-dioxadispiro[2.3.2.3]dodecane), upon treatment with various amines, was studied. Trans-isomer afforded aminoalcohols with 9-oxabicyclo[3.3.1]nonane moiety, formed via domino-process, including opening of an oxirane ring followed by intramolecular cyclization. Ring-opening of cis-isomer gave aminosubstituted cis-cyclooctane-1,5-diols, derived from independent reaction of two oxirane moieties. Activation of oxirane rings by the addition of LiClO4, acting as a Lewis acid, allowed the involvement of a number of primary and secondary aliphatic amines as well as aniline derivatives in the reaction. Scope and limitations of the reaction were studied and a series of aminoalcohols with a 9-oxabicyclo[3.3.1]nonane core and symmetric diaminodiols with a cyclooctane core were obtained.