# The Impact of Microbiome on Breast Cancer and Regulatory Strategies

## TL;DR

This paper reviews how the human microbiome influences breast cancer development and treatment through immune and inflammatory mechanisms.

## Contribution

The paper introduces a novel perspective on breast cancer by linking microbiome-driven inflammation and immunity to disease progression and treatment outcomes.

## Key findings

- The microbiome influences breast cancer progression through systemic immune-inflammatory regulation and local tumor environment remodeling.
- Microbial metabolites can alter drug metabolism and immune responses during cancer treatment.
- Targeting the microbiota may improve cancer treatment efficacy and reduce complications.

## Abstract

Breast cancer, the most prevalent malignant tumor in women, is closely linked to the human microbiota. The microbiome participates throughout breast cancer pathogenesis, including its occurrence, progression, response to anti-tumor therapies, and treatment-related complications. This review examines the central hypothesis that microbiome-driven inflammatory and immune mechanisms shape breast cancer progression through two key pathways: systemic immune-inflammatory regulation and local tumor microenvironment remodeling. Furthermore, microorganisms and their metabolites modulate systemic treatments by interfering with drug metabolism and altering systemic or local immune-inflammatory environments. Targeting the microbiota represents a promising strategy for enhancing anticancer efficacy and reducing treatment-related complications. This review aims to advance the understanding of the etiology and disease progression of breast cancer from the perspective of microbial-regulated inflammation and immunity, offering new insights for its prevention and treatment.