Two New Andrastin-Type Meroterpenoids from Marine Sponge-Derived Fungus Botryosporium sp. S5I2-1

TL;DR

Researchers discovered two new andrastin-type compounds from a marine sponge fungus but found they have limited antibacterial activity.

Contribution

The first andrastin-type meroterpenoids isolated from the Botryosporium genus, including a novel 18-norandrastin-type compound.

Findings

Two new andrastin-type meroterpenoids (1 and 2) were isolated from Botryosporium sp. S5I2-1.

Compound 1 is the first 18-norandrastin-type meroterpenoid reported.

The compounds showed no significant antibacterial activity with MIC values of 32–64 μg/mL.

Abstract

Botryomeroterpenoids A (1) and B (2), two new andrastin-type meroterpenoids, along with two known analogues (3 and 4), were isolated from sponge-derived fungus Botryosporium sp. S5I2-1. Their structures were characterized by detailed spectroscopic analysis. Meanwhile, the absolute configurations of 1 and 2 were elucidated by comparing experimental and calculated ECD spectra. Compounds 1 and 2 were the first examples of andrastin-type meroterpenoids isolated from this genus, especially Compound 1 which represented the initial instance of 18-norandrastin-type meroterpenoids. Furthermore, the antibacterial activities of all compounds were also evaluated. However, the results indicated that these compounds showed no significant inhibitory activity against the tested bacteria with minimum inhibitory concentration (MIC) values of 32–64 μg/mL.

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