# Radiolabeled Vitamins and Nanosystems as Potential Agents in Oncology Theranostics: Developed Approaches and Future Perspectives

## TL;DR

This paper reviews how radiolabeled vitamins and nanosystems can be used for both diagnosing and treating cancer, highlighting their potential in precision medicine.

## Contribution

The paper provides a critical review of current advances and proposes future directions for radiolabeled vitamins and nanosystems in oncology theranostics.

## Key findings

- Radiolabeled vitamins like B9 and B12 show promise due to their targeting properties in tumor cells.
- Nanoparticles functionalized with vitamins and labeled with isotopes could enable dual diagnostic and therapeutic functions.
- Current studies lack sufficient translational applicability for clinical use in radiotheranostics.

## Abstract

Theranostic approaches employing radioactive materials have emerged as innovative strategies that integrate molecular imaging with targeted therapy using nanosystems, thereby advancing the paradigm of precision medicine in oncology. Each year, substantial research efforts are dedicated to developing molecular probes capable of detecting early-stage tumors, with improved efficacy and reduced toxicity to the surrounding healthy tissues. Radiopharmaceuticals based on vitamins and nanoparticles are among the most promising developments in this field, as they possess a high level of specificity and low toxicity. Vitamin B9 and vitamin B12 represent notable examples, as their targeting properties exploit the overexpression of corresponding receptors in tumor cells. In this context, future directions may include the radiolabeling of nanoparticles functionalized with these vitamins using isotopes such as [68Ga] and [177Lu], thereby enabling both diagnostic imaging and therapeutic applications. Despite the encouraging preclinical evidence, many in vitro and in vivo studies employing these strategies do not sufficiently address their translational applicability to radiotheranostics. This review highlights the most promising advances in the diagnostic and therapeutic potential of vitamin and nanoparticle-based systems. It aims to critically evaluate current findings and propose hypotheses for further study in the emerging field of radiopharmaceutical theranostics.