Extracting Value from Marine and Microbial Natural Product Artifacts and Chemical Reactivity
Mark S. Butler, Robert J. Capon
TL;DR
This paper explores how reactive natural products from marine and microbial sources can transform into valuable chemical artifacts during extraction, offering new opportunities for drug discovery.
Contribution
The paper introduces a novel perspective on chemical artifacts as indicators of unique chemical spaces with enhanced properties for drug development.
Findings
Chemical artifacts from marine and microbial natural products can indicate unique and valuable chemical spaces.
Factors like solvents, heat, pH, and oxidation influence artifact formation.
Understanding and controlling artifact formation can aid in developing new marine bioproducts.
Abstract
Natural products are and continue to be a remarkable resource, rich in structural diversity, and endowed with valuable chemical and biological properties that have advanced both science and society. Some natural products, especially those from marine organisms, are chemically reactive, and during extraction and handling can partially or totally transform into artifacts. All too often overlooked or mischaracterised as natural products, artifacts can be invaluable indicators of a uniquely evolved and primed chemical space, with enhanced chemical and biological properties highly prized for drug discovery. To demonstrate this potential, we review a wide selection of marine and microbial case studies, revealing the factors that initiate artifact formation (e.g., solvents, heat, pH, light and air oxidation) and commenting on the mechanisms behind artifact formation. We conclude with…
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25
Figure 26
Figure 27
Figure 28
Figure 29
Figure 30
Figure 31
Figure 32
Figure 33
Figure 34
Figure 35
Figure 36
Figure 37
Figure 38
Figure 39
Figure 40
Figure 41
Figure 42
Figure 43
Figure 44
Figure 45
Figure 46
Figure 47
Figure 48
Figure 49
Figure 50Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsMicrobial Natural Products and Biosynthesis · Marine Sponges and Natural Products · Seaweed-derived Bioactive Compounds