# Catching the Storm Before It Breaks: Advancing Early Diagnosis and Intervention in Bipolar Disorder

**Authors:** Marianna Mazza, Luca Chisari, Francesco Maria Lisci, Caterina Brisi, Giovanni Camardese, Domenico De Berardis, Luigi Janiri, Gabriele Sani, Giuseppe Marano

PMC · DOI: 10.3390/life16010007 · Life · 2025-12-20

## TL;DR

This paper reviews how early diagnosis and intervention in bipolar disorder can improve outcomes by identifying risk markers and implementing timely mental health strategies.

## Contribution

The paper provides a comprehensive review of current research on early stages of bipolar disorder and emphasizes integrated approaches for early intervention.

## Key findings

- Early identification and intervention in bipolar disorder can delay onset and reduce episode severity.
- Combining biomarkers, risk models, and youth mental health services is crucial for effective early intervention.
- Longitudinal studies and personalized strategies are needed to address ethical and practical challenges.

## Abstract

In recent years, growing attention has been directed toward the early diagnosis and intervention of bipolar disorder (BD), driven by the recognition that timely clinical action may significantly alter the trajectory of the illness. Early identification of individuals at risk, as well as intervention during prodromal or subthreshold phases, offers the potential to delay onset, reduce episode severity, improve long-term outcomes, and possibly prevent the full manifestation of the disorder. This narrative review aims to provide a comprehensive overview of the current literature on the early stages of BD, including clinical high-risk states, neurobiological and cognitive markers, and psychosocial indicators. It also explores the latest research findings and their implications for clinical practice, highlighting the importance of integrated approaches that combine biomarker discovery, risk stratification models, and youth-focused mental health services. Finally, the review discusses the ethical and practical challenges of early intervention and underscores the need for further longitudinal studies and personalized preventive strategies.

## Linked entities

- **Diseases:** bipolar disorder (MONDO:0004985)

## Full-text entities

- **Diseases:** BD (MESH:D001714)

## Full text

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## References

99 references — full list in the complete paper: https://tomesphere.com/paper/PMC12843314/full.md

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Source: https://tomesphere.com/paper/PMC12843314