# Oral Manifestations of Sjögren’s Syndrome: Recognition, Management, and Interdisciplinary Care

**Authors:** Shu-Cheng Liu, Ming-Chi Lu, Malcolm Koo

PMC · DOI: 10.3390/medicina62010005 · Medicina · 2025-12-19

## TL;DR

This paper discusses how to recognize and manage oral symptoms of Sjögren’s Syndrome, emphasizing early detection and interdisciplinary care to prevent tooth loss and improve patient comfort.

## Contribution

The paper introduces structured referral pathways and practical salivary metrics for early SS detection in rheumatology settings.

## Key findings

- Early oral signs of SS include rapid caries, burning sensations, and increased dental treatment needs.
- Unstimulated whole saliva ≤ 0.1 mL/min supports hypofunction and aids SS diagnosis.
- Preventive care combining dietary counseling and salivary stimulation can reduce tooth loss.

## Abstract

Background and Objectives: Sjögren’s syndrome (SS) causes destructive salivary gland dysfunction with substantial oral morbidity. To synthesize practical, evidence-based approaches for early recognition, initial oral management, and timely referral to dental care. Materials and Methods: Narrative review of English-language literature from the Web of Science Core Collection and PubMed, prioritizing systematic reviews, randomized trials, and consensus guidelines. Results: Early oral signs include rapid multifocal root and cervical caries, burning sensations, and rising dental treatment needs. Unstimulated whole saliva ≤ 0.1 mL/min supports significant hypofunction and complements the 2016 ACR/EULAR criteria. Preventive care should combine dietary counseling, salivary stimulation, and topical remineralization. Adjuncts include high-fluoride toothpaste, biomimetic hydroxyapatite dentifrices, and casein phosphopeptide–amorphous calcium phosphate (CPP-ACP). However, evidence for fluoride varnish in SS remains mixed. Pharmacologic sialogogues require screening for contraindications. Conclusions: Embedding oral screening, simple salivary metrics, and a structured referral pathway into rheumatology visits can reduce preventable tooth loss and improve comfort, function, and treatment adherence.

## Linked entities

- **Chemicals:** fluoride (PubChem CID 28179), hydroxyapatite (PubChem CID 14781)

## Full-text entities

- **Diseases:** caries (MESH:D003731), tooth loss (MESH:D016388), salivary gland dysfunction (MESH:D012466), SS (MESH:D012859)
- **Chemicals:** hydroxyapatite (MESH:D017886), fluoride (MESH:D005459), CPP-ACP (-)

## Full text

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## Figures

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## References

65 references — full list in the complete paper: https://tomesphere.com/paper/PMC12843269/full.md

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Source: https://tomesphere.com/paper/PMC12843269