# Biomaterials for Improving Skin Penetration in Treatment of Skin Cancer

## TL;DR

This paper reviews how biomaterials can help improve drug delivery through the skin for better skin cancer treatment.

## Contribution

The paper provides a comprehensive review of functional biomaterials designed to overcome skin barriers for drug delivery.

## Key findings

- The skin barrier significantly limits the effectiveness of topical drug delivery for skin cancer.
- Functional biomaterials show promise in enhancing drug penetration through the skin.
- Formulation strategies must consider drug properties and release mechanisms for optimal delivery.

## Abstract

Skin cancer is among the most common malignancies worldwide, posing a significant societal burden due to its increasing incidence and its limited responsiveness to conventional topical therapies. Treatment is challenged by the presence of the skin barrier which restricts drug penetration. This review discusses the structural and physiological challenges of topical delivery and summarizes efforts to develop functional biomaterials to enhance skin drug penetration. Important aspects to consider when developing formulation strategies, such as drug properties and release mechanisms, are discussed alongside current limitations and future perspectives.