# Mg Alloys Reduce Gastric Cancer and Mediate Therapeutic Management of Antibacterial Function

## TL;DR

This study shows that Mg alloys can inhibit gastric cancer cell growth and reduce tumor volume in mice, while also showing antibacterial effects against harmful bacteria.

## Contribution

The novel contribution is the preclinical demonstration of Mg alloys as a potential therapeutic material for gastric cancer treatment.

## Key findings

- Mg alloys inhibited MGC-803 cell viability in co-culture experiments.
- Implantation of Mg alloys reduced tumor volume by 42.86% in tumor-bearing mice.
- Mg alloys inhibited bacterial growth of Escherichia coli and Staphylococcus aureus by approximately 70%.

## Abstract

Background: Gastric cancer (GC) represents a significant challenge in global public health, and novel treatment strategies are urgently needed. This study investigated the potential application of Mg alloys for the treatment of GC through preclinical experimentation. Methods: Alloy materials were screened and selected in GC cells using cell viability assays. To uncover the mechanisms by which Mg alloys influence GC, RNA sequencing and qRT-PCR were performed. Mice bearing tumors derived from GC cells were used to assess the potential application of Mg alloys in GC. The antibacterial effects of Mg alloys were evaluated in Escherichia coli and Staphylococcus aureus. Results: Co-cultures of Mg alloys with MGC-803 cells resulted in inhibition of cell viability. RNA sequencing revealed differential mRNA expression and we validated the gene expression changes. Moreover, Mg alloy wire implantation effectively displayed that the inhibition rate of relative tumor volume reached 42.86% in tumor-bearing mice. Additionally, Mg alloys inhibited bacterial growth of two types of pathogenic bacteria, with an antibacterial rate of approximately 70%. Conclusions: Our results indicate that Mg alloys represent a novel therapeutic resource for clinical applications against GC.