# GDM-Related Neurodevelopmental and Neuropsychiatric Disorders in the Mothers and Their Progeny, and the Underlying Mechanisms

**Authors:** Zhijin Yan, Jianhong Pu, Dawei Li, Mingxing Liu, Zhice Xu, Jiaqi Tang

PMC · DOI: 10.3390/jpm16010019 · Journal of Personalized Medicine · 2026-01-04

## TL;DR

This paper reviews how gestational diabetes affects the mental health of mothers and their children, and explores the possible causes behind these effects.

## Contribution

The paper provides a comprehensive review of neuropsychiatric disorders linked to GDM and their potential mechanisms.

## Key findings

- GDM is associated with neuropsychiatric disorders in both mothers and their offspring.
- The paper identifies potential underlying mechanisms linking GDM to these disorders.
- The findings suggest a need for personalized strategies to address these health issues.

## Abstract

Gestational diabetes mellitus (GDM) has witnessed a persistent rise in the prevalence over the past few decades, imposing a substantial burden on global health and economies. GDM exerts both short-term and long-term effects on neuropsychiatric systems of the mothers and their progeny. This review catalogs the neurodevelopmental and neuropsychiatric disorders in GDM women and their offspring and summarizes the possible relationships as well as the underlying mechanisms, which would enhance our understanding of the neuropsychiatric disorders related to GDM, offering information on personalized strategies for patients.

## Linked entities

- **Diseases:** Gestational diabetes mellitus (MONDO:0005406)

## Full-text entities

- **Diseases:** GDM (MESH:D016640), Neurodevelopmental and Neuropsychiatric Disorders (MESH:D001523), neuropsychiatric (MESH:C000631768)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12843108/full.md

## References

159 references — full list in the complete paper: https://tomesphere.com/paper/PMC12843108/full.md

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Source: https://tomesphere.com/paper/PMC12843108