# Relationship Between Clinical Factors and the Risk of Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage: An Exploratory Analysis

## TL;DR

This study explores how blood parameters and demographics relate to the risk of cerebral vasospasm after subarachnoid hemorrhage.

## Contribution

The study identifies novel associations between blood parameters and vasospasm risk in aneurysmal subarachnoid hemorrhage patients.

## Key findings

- Elevated white blood cell counts and neutrophil-to-lymphocyte ratio are linked to symptomatic vasospasm.
- Lower platelet counts are significantly associated with vasospasm occurrence.
- Younger age and female gender correlate with increased vasospasm risk.

## Abstract

Background/Objectives: Cerebral subarachnoid hemorrhage (SAH) from ruptured aneurysms poses significant morbidity and mortality risks. Among survivors, cerebral vasospasm can develop, increasing complications. This study investigates the relationship between blood parameters and the risk of vasospasm. Methods: We analyzed clinical data from patients with SAH—both with and without vasospasm—and healthy controls. Statistical analyses, including Spearman’s rank correlation and univariate analysis, were conducted. Results: Significant differences were observed between patients with and without vasospasm. Elevated white blood cell counts, a higher neutrophil-to-lymphocyte ratio, and lower platelet counts showed a significant association with symptomatic vasospasm. Younger age and female gender were associated with a higher risk. Conclusions: These preliminary findings highlight the importance of specific blood parameters and demographic factors in assessing the risk of cerebral vasospasm in SAH patients, supporting early risk stratification and monitoring to improve outcomes; however, these results require validation in larger cohorts.